MMV009085 is a potent and selective inhibitor of the Plasmodium falciparum hexose transporter (PfHT1), designed to target malaria by blocking glucose uptake, with an IC50 of 2.6 μM for the transporter and an EC50 of 1.23 μM against the 3D7 strain. It acts as a probe-like molecule with high selectivity for PfHT1 over human glucose transporters (GLUTs). In vitro, it shows selective inhibition of Neospora caninum tachyzoite proliferation in infected host cell assays, with an IC₅₀ of approximately 150 ± 30 nM, while also displaying activity against related apicomplexan pathogens such as Cryptosporidium parvum. Mechanistically, related studies suggest MMV009085 may interfere with hexose transport–dependent metabolism, likely acting as a glucose transporter mimic or inhibitor, thereby disrupting parasite energy uptake and intracellular replication.

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.