Deucravacitinib(BMS986165) Datasheet DC Chemicals
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Cat.No DC12174
Name Deucravacitinib(BMS986165)

Chemical Properties

CAS 1609392-27-9
Formula C20H19D3N8O3
MW 425.46
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target:
In Vivo Lupus-like disease is strongly inhibited in NZB/W mice treated with Tyk2-IN-4. Tyk2-IN-4 is safe and overall well-tolerated. There are no serious adverse events and the frequency of non-serious adverse events are similar in the active (75%) and placebo (76%) groups. After oral administration, Tyk2-IN-4 is rapidly absorbed and exhibits an apparent elimination half-life of 8-15 hours[1].
In Vitro Tyk2-IN-4 blocks receptor-mediated Tyk2 activation by stabilizing the regulatory pseudokinase domain of the protein[1].
Kinase Assay
Cell Assay
Animal Administration

References

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