4A3-SCC-10 is a disulfide bond-containing biodegradable ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing 4A3-SCC-10 and encapsulating a Cy5-RNA reporter have improved endosomal escape ability over Cy5-RNA-encapsulated LNPs containing 4A3-SC-10, which does not contain disulfide bonds, in HeLa cells. Intravenous administration of LNPs containing 4A3-SCC-10 and encapsulating an mRNA luciferase reporter selectively accumulate in mouse liver.
Cat.No
DC60508
Name
4A3-SCC-10
Chemical Properties
CAS
Formula
C91H171N3O16S12
MW
1948.1
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
1. Ansell, S.M., and Du, X. Lipids and lipid nanoparticle formulations for delivery of nucleic acids. US 10,166,298 B2, (2019).
2. Lin, J.C.P., and Tam, Y. Lipid delivery of therapeutic agents to adipose tissue. (2018).
3. Sahin, U., Lindemann, C., Diekmann, J., et al. RNA compositions targeting claudin-18.2. (2021).
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