The 6Ac1-C12 LNPs exhibit a pKa of ~6.0, enabling pH-responsive endosomal escape. They demonstrate high stability (maintaining ~100 nm size for 30 days at 4°C) and efficient mRNA encapsulation. With slightly negative surface charge, these nanoparticles show serum resistance. The liver-targeted formulation (4-component) achieves 98% hepatic mRNA expression, primarily in endothelial (60%) and Kupffer cells. The cholesterol-free 3-component lung-targeted version eliminates hepatic accumulation while enabling 71% transfection in pulmonary endothelial cells. Both formulations maintain structural integrity post-dialysis and show low cytotoxicity, with lung-targeted LNPs exhibiting reduced lipoprotein adsorption for enhanced organ specificity.
Cat.No
DC60809
Name
6Ac1-C12
Chemical Properties
CAS
Formula
MW
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
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