93-O17O is a chalcogen-containing ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs). LNPs containing 93-O17O localize to the spleen after intravenous injection into mice.LNPs containing 93-O17O have been used for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice and for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens.
Cat.No
DC82105
Name
93-O17O
Chemical Properties
CAS
2227214-78-8
Formula
750.2
MW
C44H83N3O6
Storage
References
1. Zhao, X., Chen, J., Qiu, M., et al. Imidazole-based synthetic lipidoids for in vivo mrna delivery into primary T lymphocytes. Angew. Chem. Int. Ed. Engl. 59(45), 20083-20089 (2020).
2. Chen, J., Qiu, M., Ye, Z., et al. In situ cancer vaccination using lipidoid nanoparticles. Sci. Adv. 7(19), eabf1244 (2021).
3. Li, Y., Yang, T., Yu, Y., et al. Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteins. Biomaterials 178, 652-662 (2018).
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