98N12-5 Datasheet DC Chemicals

Description	98N12-5 is an ionizable cationic lipid. It has been used in combination with other lipids in the generation of lipid nanoparticles (LNPs). LNPs containing 98N12-5 and encapsulating proprotein convertase subtilisin kexin type 9 (PCSK9) siRNA selectively accumulate in the liver and reduce total serum cholesterol levels in mice and rats and serum LDL levels in cynomolgus monkeys.
Cat.No	DC70010
Name	98N12-5

Chemical Properties

CAS	917572-74-8
Formula	C81H163N9O5
MW	1343.22
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Akinc A, Goldberg M, Qin J, et al. Development of lipidoid-siRNA formulations for systemic delivery to the liver. Mol Ther. 2009;17(5):872-879. [2]. Nguyen DN, Chen SC, Lu J, et al. Drug delivery-mediated control of RNA immunostimulation. Mol Ther. 2009;17(9):1555-1562.

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