A066 is a lipid for RNA and vaccine delivery.A-066 is an analog of DODMA that contains a pyrrole
head group. A-066 LNPs encapsulating TetR siRNA could induce significant antitumor efficacy in orthotopic hepatocellular carcinoma models.
Cat.No
DC83320
Name
A-066
Chemical Properties
CAS
1192362-77-8
Formula
C43H79NO2
MW
641.6111
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
Li, L.; Wang, R.; Wilcox, D.; Sarthy, A.; Lin, X.; Huang, X.; Tian,
L.; Dande, P.; Hubbard, R. D.; Hansen, T. M.; et al. Developing Lipid
Nanoparticle-Based siRNA Therapeutics for Hepatocellular Carcinoma
Using an Integrated Approach. Mol. Cancer Ther. 2013, 12, 2308.2318.
(487) Niculescu-Duvaz, D.; Heyes, J.; Springer, C. Structure-Activity
Relationship in Cationic Lipid Mediated Gene Transfection. Curr. Med.
Chem. 2003, 10, 1233.1261.
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