A 438079 is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.
Cat.No
DC26144
Name
A 438079
Chemical Properties
CAS
899507-36-9
Formula
C13H9CL2N5
MW
306.15
Storage
2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
References
[1]. McGaraughty S, et al. P2X7-related modulation of pathological nociception in rats. Neuroscience. 2007 Jun 8;146(4):1817-28.
[2]. Mesuret G, et al. CNS Neurosci Ther. 2014 Jun;20(6):556-64.
[3]. Marcellino D, et al. On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079. J Neural Transm (Vienna). 2010 Jun;117(6):681-7.
[4]. Martins JP, et al. The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice. Br J Pharmacol. 2012 Jan;165(1):183-96.
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