A77 1726 Datasheet DC Chemicals
Description Teriflunomide, aslo known as A77 1726, is the active metabolite of leflunomide. Teriflunomide is an immunomodulatory drug inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase. It is uncertain whether this explains its effect on MS lesions. Teriflunomide inhibits rapidly dividing cells, including activated T cells, which are thought to drive the disease process in MS. It has been found that teriflunomide blocks the transcription factor NF-κB. The drug was approved by the FDA on September 13, 2012.
Cat.No DC31334
Name A77 1726

Chemical Properties

CAS 108605-62-5
Formula C12H9F3N2O2
MW 270.20727
Storage

References

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