N-(p-Amylcinnamoyl) anthranilic Acid (ACA) Datasheet DC Chemicals
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Cat.No DC12492
Name N-(p-Amylcinnamoyl) anthranilic Acid (ACA)

Chemical Properties

CAS 110683-10-8
Formula C21H23NO3
MW 337.41222
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：110683-10-8
Product Name：Benzoic acid,2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-
Synonyms：Benzoic acid,2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-;ACA;N-(p-amylcinnamoyl) Anthranilic Acid;N-(P-AMYLCINNAMOYL)- ANTHRANILIC ACID;4-amylcinnamoylanthranilicacid;N-(P-AMYLCINNAMOYL)ANTHRANILIC ACID;N-(p-Amylcinnamoyl) anthranilic Acid (ACA);2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID
EINEC:
Molecular Formula：C21H23NO3
Molecular Weight：337.41222
Target: PLA2[1][2]. TRP channel[1][2].Calcium-activated chloride channels[3].
In Vivo
In Vitro N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) completely blocks ADPR-induced whole-cell currents and H2O2-induced Ca2+ signals (IC50=1.7 μM) in HEK293cells transfected with human TRPM2[1]. N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) also blocks currents through human TRPM8 and TRPC6 expressed in HEK293 cells[1]. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) modulates the activity of different TRP channels independent of PLA22 inhibition[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Kraft R, et al. Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73. [2]. Harteneck C, et al. N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker. Cardiovasc Drug Rev. 2007 Spring;25(1):61-75. [3]. Gwanyanya A, et al. Inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by N-(p-amylcinnamoyl)anthranilic acid (ACA). Biochem Biophys Res Commun. 2010 Nov 19;402(3):531-6.
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