ACBI3 Datasheet DC Chemicals
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Cat.No DC60518
Name ACBI3

Chemical Properties

CAS 2938169-76-5
Formula C50H62N14O6S2
MW 1,019.260
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：2938169-76-5
Product Name：ACBI3; ACBI 3; ACBI-3;
Synonyms：1-(2-(4-(4-(4-(4-(5-(2-amino-3-cyano-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-yl)-1,2,4-oxadiazol-3-yl)pyrimidin-2-yl)-3-methyl-1,4-diazepan-1-yl)butoxy)-1H-1,2,3-triazol-1-yl)-3-methylbutanoyl)-4-hydroxy-N-(2-hydroxy-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
EINECS:
Molecular Formula：C50H62N14O6S2
Molecular Weight：1,019.260
Target:
In Vivo
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

Johannes Popow et al., Targeting cancer with small-molecule pan-KRAS degraders. Science (2024). DOI: 10.1126/science.adm8684 [2] Adrienne D. Cox and Channing J. Der. KRAS takes the road to destruction. Science (2024). DOI: 10.1126/science.ads2150[3] Kim, D., Herdeis, L., Rudolph, D. et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature (2023). https://doi.org/10.1038/s41586-023-06123-3
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