ACBI3 Datasheet DC Chemicals

Description	ACBI3 is a selective, potent and in vivo active pan-KRAS PROTAC degrader, potently degrades 13 out of 17 of the most prevalent oncogenic KRAS alleles (DC50=3.9 nM in GP2d cells).
Cat.No	DC60518
Name	ACBI3

Chemical Properties

CAS	2938169-76-5
Formula	C50H62N14O6S2
MW	1,019.260
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

Johannes Popow et al., Targeting cancer with small-molecule pan-KRAS degraders. Science (2024). DOI: 10.1126/science.adm8684 [2] Adrienne D. Cox and Channing J. Der. KRAS takes the road to destruction. Science (2024). DOI: 10.1126/science.ads2150[3] Kim, D., Herdeis, L., Rudolph, D. et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature (2023). https://doi.org/10.1038/s41586-023-06123-3

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