AG-2037 Datasheet DC Chemicals
Description Pelitrexol is a GARFT inhibitor, and is also a water soluble antifolate with anti-proliferative activity. Pelitrexol inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme of the de novo purine synthesis pathway essential for cell proliferation. Enzyme inhibition reduces the purine nucleotides pool required for DNA replication and RNA transcription. As a result, this agent causes cell cycle arrest in S-phase, and ultimately inhibits tumor cell proliferation.
Cat.No DC31269
Name AG-2037

Chemical Properties

CAS 446022-33-9
Formula C20H25N5O6S
MW 463.5074
Storage

References

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