APS-2-79 hydrochloride Datasheet DC Chemicals
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Cat.No DC9808
Name APS-2-79 hydrochloride

Chemical Properties

CAS 2002381-31-7
Formula C23H22CLN3O3
MW 423.8921
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：2002381-31-7
Product Name：APS-2-79 hydrochloride
Synonyms：APS-2-79 (hydrochloride);APS 2-79 hydrochloride;6,7-Dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine hydrochloride;APS279 hydrochloride;BCP23567;s8355;AK685587;6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine HCl;APS-2-79 hydrochloride
EINEC:
Molecular Formula：C23H22CLN3O3
Molecular Weight：423.8921
Target:
In Vivo
In Vitro APS-2-79 (1 μM) shifts the cell viability dose response to Trametinib in Ras-mutant cell lines HCT-116 and A549, but not BRAF mutant cell lines SK-MEL-239 and A375. Although the cellular effects of APS-2-79 alone are modest, combination analysis over full concentration matrices reveal that kinase suppressor of Ras (KSR)-inactive state (KSRi) synergizes with Trametinib, and other MEK inhibitors, specifically in KRAS mutant cell lines. APS-3-77, and additional control compounds, do not demonstrate Ras-mutant-specific synergy, supporting the hypothesis that the enhanced activity of Trametinib when combined with APS-2-79 depends on co-modulation of KSR[1].
Kinase Assay
Cell Assay
Animal Administration

References

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