AT-527(Bemnifosbuvir hemisulfate) Datasheet DC Chemicals
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Cat.No DC39024
Name AT-527(Bemnifosbuvir hemisulfate)

Chemical Properties

CAS 2241337-84-6
Formula C24H33FN7O7P.1/2H2O4S
MW 630.53
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.:2241337-84-6
Product Name:AT-527
Synonyms:AT527;AT 527
EINECS:
Molecular Formula:C24H33FN7O7P.1/2H2O4S
Molecular Weight:630.53
Target:
In Vivo
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Steven S Good, et al. Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus. PLoS One. 2020 Jan 8;15(1):e0227104. [2]. Steven S Good, et al. AT-527, a double prodrug of a guanosine nucleotide analog, is a potent inhibitor of SARS-CoV-2 in vitro and a promising oral antiviral for treatment of COVID-19. Antimicrob Agents Chemother. 2021 Feb 8;AAC.02479-20. [3]. Elina Berliba, et al. Safety, pharmacokinetics and antiviral activity of AT-527, a novel purine nucleotide prodrug, in HCV-infected subjects with and without cirrhosis. Antimicrob Agents Chemother. 2019 Sep 30;63(12):e01201-19.
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