AZ3451 Datasheet DC Chemicals

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Cat.No	DC10879
Name	AZ3451

Chemical Properties

CAS	2100284-59-9
Formula	C30H27BRN4O3
MW	571.4644
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description	CAS NO.：2100284-59-9 Product Name：2-(6-Bromanyl-1,3-Benzodioxol-5-Yl)-~{n}-(4-Cyanophenyl)-1-[(1~{s})-1-Cyclohexylethyl]benzimidazole-5-Carboxamide Synonyms：2-(6-Bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide;AZ3451;(S)-2-(6-bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1H-benzo[d]imidazole-5-carboxamide;AZ 3451;2-(6-Bromanyl-1,3-Benzodioxol-5-Yl)-~{n}-(4-Cyanophenyl)-1-[(1~{s})-1-Cyclohexylethyl]benzimidazole-5-Carboxamide;(S)-2-(6-Bromobenzo[d][1,3]dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1Hbenzo[d]imidazole-5-carboxamide;GTPL9560;BDBM50274114;s9744;2-(6-Bromo-1,3-benzodioxol- EINEC: Molecular Formula：C30H27BRN4O3 Molecular Weight：571.4644
Target:
In Vivo
In Vitro	Antagonist AZ3451 binds to a remote allosteric site outside the helical bundle of the protease-activated receptor 2. AZ3451 is highly lipophilic, which coincides with the hydrophobic nature of the binding pocket within the membrane. Antagonist binding prevents structural rearrangements required for receptor activation and signalling[1].
Kinase Assay
Cell Assay
Animal Administration

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