AZD-1208 Datasheet DC Chemicals
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Cat.No DC5012
Name AZD-1208

Chemical Properties

CAS 1204144-28-4
Formula C21H21N3O2S
MW 379.4753
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：1204144-28-4
Product Name：AZD-1208
Synonyms：AZD1208;(R,Z)-5-((2-(3-Aminopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)methylene)thiazolidine-2,4-dione;AZD-?1208;Azd-1208;AZD 1208;S98NFM1378;GTPL7698;AK174910;(5Z)-5-[[2-[(3R)-3-aminopiperidin-1-yl]-3-phenylphenyl]methylidene]-1,3-thiazolidine-2,4-dione;(5Z)-5-({2-[(3R)-3-Aminopiperidin-1-yl]-3-phenylphenyl}methylidene)-1,3-thiazolidine-2,4-dione;AOB87151;s7104;2236AH;BDBM50387298;5-[[2-[(3R)-3-Aminopiperidin-1-yl]biphenyl-3-yl]methylidene]-1,3-thiazolidine-2,4-dione;BDB
EINECS:
Molecular Formula：C21H21N3O2S
Molecular Weight：379.4753
Target:
In Vivo
In Vitro AZD1208 shows good antiproliferative activity in a megakaryoblastic leukemia cell line, MOLM-16, with GI50 values less than 100 nM[1]. AZD1208 (10 μM) inhibits the growth of Ramos cells, and at 1 μM, strongly inhibits PIM kinases in all cell at 1 μM. AZD1208 induces apoptosis, and PIM2 knockdown is mainly associated with an alteration of the cell cycle[2]. The combination of AZD1208 and AZD2014 rapidly activates AMPKα, a negative regulator of translation machinery through mTORC1/2 signaling in AML cells; profoundly inhibits AKT and 4EBP1 activation; and suppresses polysome formation[3].
Kinase Assay
Cell Assay
Animal Administration

References

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