AZD-7624 Datasheet DC Chemicals
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Cat.No DC20242
Name AZD-7624

Chemical Properties

CAS 1095004-78-6
Formula C27H30FN5O3
MW 491.5572
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：1095004-78-6
Product Name：N-Cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopyrazin-1-yl]benzamide
Synonyms：N-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-benzamide;AZD7624;3P4CR02JTD;AZD 7624 [WHO-DD];NNKPHNTWNILINE-UHFFFAOYSA-N;s8734;J3.631.182G;N-Cyclopropyl-3-fluoro-5-[3-[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropylamino]-2-oxo-1,2-dihydropyrazine-1-yl]-4-methylbenzamide;N-Cyclopropyl-3-fluoro-4-methyl-5-(3-((1-(2-(2-(methylamino)ethoxy)phenyl)cyclopropyl)amino)-2-oxopyrazin-1(2H)-yl)benzamide;N-Cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]a;N-Cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopy
EINEC:
Molecular Formula：C27H30FN5O3
Molecular Weight：491.5572
Target:
In Vivo
In Vitro AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624 inhibits LPS-induced TNFα in human mononuclear cells, in whole blood as well as in alveolar macrophages in vitro, with pIC50u of 8.4, 8.7, and 9.0[1].
Kinase Assay
Cell Assay
Animal Administration

References

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