AZ-6102 Datasheet DC Chemicals
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Cat.No DC7926
Name AZ-6102

Chemical Properties

CAS 1645286-75-4
Formula C25H28N6O
MW 428.5294
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：1645286-75-4
Product Name：2-(4-(6-((3R,5S)-3,5-Dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
Synonyms：AZ6102;AZ-6102;AZ 6102;2-(4-(6-((3R,5S)-3,5-dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one;BCP16242;BDBM50232346;s7767;SB17458;J3.659.362H;2-(4-{6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-4-methylpyridin-3-yl}phenyl)-7-methyl-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one;2-[4-[6-[(3S,5R)-3,5-dimethylpipera
EINEC:
Molecular Formula：C25H28N6O
Molecular Weight：428.5294
Target:
In Vivo
In Vitro AZ6102 is a potent dual TNKS1 and TNKS2 inhibitor, with IC50s of 3 nM and 1 nM, respectively. AZ6102 alao has 100-fold selectivity against other PARP family enzymes, with IC50s of 2.0 μM, 0.5 μM, and >3 μM, for PARP1, PARP2, and PARP6, respectively. AZ6102 shows Wnt pathway inhibition in DLD-1 cells[1].
Kinase Assay
Cell Assay
Animal Administration

References

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