AF-2364, an analogue of Lonidamine (LND), had a contraceptive effect when orally administered to adult Sprague–Dawley rats.
Cat.No
DC8355
Name
Adjudin (AF-2364)
Chemical Properties
CAS
252025-52-8
Formula
C15H12N4OCL2
MW
335.18798
Storage
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
References
Mice[3] The male BALB/C nude mice weighing ~20g are equally implanted with A549 cells (0.5×107 cells) containing 3 mg/mL of matrigel and PC3 cells (1×106 cells) hypodermically. After 2 weeks, the mice with palpable tumors are divided into two groups (n=4 per group in each experiment and repeated with a total of three experiments): i.p. injection of Adjudin which is dissolved in corn oil from a DMSO stock solution with final administered quantity at 100 mg/kg (~300 µM used in vitro); the equivalent vehicle control group are administered with the same amount of corn oil and DMSO via i.p. injection. Adjudin or vehicles are administered every three day in A549 and every other day in PC3 up to 2 weeks. Tumor volumes are determined and calculated.
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