Alemtuzumab Datasheet DC Chemicals
Description Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein,CD52. The Campath-1H antibody is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). Campath is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium containing neomycin.
Cat.No A028
Name Alemtuzumab

Chemical Properties

CAS 216503-57-0
Synonyms Immunoglobulin G1,anti-(human CD52 (antigen)) (human-rat monoclonal CAMPATH-1H g1-chain), disulfide withhuman-rat monoclonal CAMPATH-1H light chain, dimer (9CI);ALEMTUZUMAB;Immunoglobulin G1,anti-(human CD52 (antigen)) (human-rat monoclonal CAMPATH-1H g1-chain), disulfide withhuman-rat monoclonal ;Alemtuzumab (usan/inn);Alemtuzumab (usan/inn);Campath (tn);Campath (tn);D02802;D02802;MabCampath;MabCampath;Research Grade Alemtuzumab(DHD95101);Research Grade Alemtuzumab(DHD95101);Research Grade Alemtuzumab;Research Grade Alemtuzumab
pH value Corresponds to reference standard: PASS
Non-reduced CE-SDS 98.5%
SEC-HPLC 99.4%
Isoelectric Point Corresponds to reference standard
Bacterial Endotoxins Test <1 EU/ml
Residual Proteins of Host Cell
Exogenous Residual DNA <1 pg/mg
Residual protein A <1 ng/mg
Biological Activity Compared with standard, the range ofbiological activity is 91%
Osmolality Corresponds to reference standard: PASS
Peptide mapping Corresponds to reference standard: PASS
N-terminal sequence Corresponds to reference standard:PASS

References

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