BD750 Datasheet DC Chemicals

Description	BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively.
Cat.No	DC40513
Name	BD750

Chemical Properties

CAS	892686-59-8
Formula	C14H13N3OS
MW	271.337521314621
Storage	Powder-20°C3 yearsIn solvent-80°C6 months-20°C1 month

References

[1]. Y Liu, et al. BD750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK3/STAT5 signalling pathway. Br J Pharmacol. 2013 Feb;168(3):632-43. [2]. Yan Zhou, et al. Tolerogenic dendritic cells induced by BD750 ameliorate proinflammatory T cell responses and experimental autoimmune encephalitis in mice. Mol Med. 2017 Oct;23:204-214.

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