BTSA1.2 Datasheet DC Chemicals

Description	BTSA1.2 is a rationalized BTSA1 analog with improved binding to BAX, cellular cytotoxicity, and better toleratence in vivo. Combination of BTSA1.2 with Navitoclax demonstrates synergistic efficacy in apoptosis-resistant cancer cells, xenografts, and patient-derived tumors while sparing healthy tissues.
Cat.No	DC59120
Name	BTSA1.2

Chemical Properties

CAS	2254256-66-9
Formula	C23H18N6OS2
MW	458.56
Storage	-20

References

[1] Promising approach against treatment-resistant cancer. Retrieved Mar 8th, 2022 from https://medicalxpress.com/news/2022-03-approach-treatment-resistant-cancer.html [2] Andrea Lopez et al, Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer, Nature Communications (2022). DOI: 10.1038/s41467-022-28741-7

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