2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：850717-64-5 Product Name：Urea, (2,3-dihydro-2-oxo-3-(1-(1H-pyrrol-2-yl)ethylidene)-1H-indol-5-yl)- Synonyms：BX517(PDK1 inhibitor2);BX517;SYV8VN8W5K;Urea, (2,3-dihydro-2-oxo-3-(1-(1H-pyrrol-2-yl)ethylidene)-1H-indol-5-yl)-;pdk-1 inhibitors;Urea, [2,3-dihydro-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-1H-indol-5-yl]-;PDK1 inhibitor2;Indolinone based inhibitor, 4i;5-Ureido-3-(1-(pyrrol-2-yl)ethylidene)indolin-2-one;BDBM17004;BCP16225;s6504;Urea, N-(2,3-dihydro-2-oxo-3-((3Z)-1-(1H-pyrrol-2-yl)ethylidene)-1H-indol-5-yl EINEC: Molecular Formula：C15H14N4O2 Molecular Weight：282.29700
Target:
In Vivo
In Vitro
BX-517 blocks activation of Akt in tumor cells, is potent with IC50 of 0.1-1.0 μM[1]. BX-517 blocks AKT2 activation in cells with submicromolar potency. BX-517 is 100-fold selective or better against a panel of seven additional Ser/Thr and Tyr kinases[2].
Kinase Assay
Cell Assay
Animal Administration
References
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