Bevacizumab Datasheet DC Chemicals
Description Bevacizumab (anti-VEGF) is a humanized anti-VEGF monoclonal antibody which binds to and neutralizes all human VEGF-A isoforms and bioactive proteolytic fragments.
Cat.No A005
Name Bevacizumab

Chemical Properties

CAS 216974-75-3
Synonyms Avastin;BEVACIZUMAB;BevacizuMab [USAN:INN];Anti-vegf monoclonal antibody;Bevacizumab;Immunoglobulin G1, anti-(human vascular endothelial growth factor) (human-mouse monoclonal rhumab-vegf gamma1-chain), disulfide with human-mouse monoclonal rhumab-vegf light chain, dimer;Immunoglobulin G1, anti-(human vascular endothelial growth factor) (human-mouse monoclonal rhumab-vegf gamma1-chain), disulfide with human-mouse monoclonal rhumab-vegf light chain, dimer;Rhumab-vegf;Rhumab-vegf;Unii-2S9zzm9Q9v;Unii-2S9zzm9Q9v;Avastatin;Avastatin
pH value Corresponds to reference standard： PASS
Non-reduced CE-SDS 98.9%
SEC-HPLC 99.4%
Isoelectric Point Corresponds to reference standard:PASS
Bacterial Endotoxins Test ＜1 EU/ml
Residual Proteins of Host Cell
Exogenous Residual DNA ＜1 pg/mg
Residual protein A ＜1 ng/mg
Biological Activity Compared with standard, the range of biological activity is 113%
Osmolality Corresponds to reference standard: PASS
Peptide mapping Corresponds to reference standard: PASS
N-terminal sequence Corresponds to reference standard:PASS

References

[1]. Liu W, et al. Effect of Avastin on the migration and invasion of pterygium fibroblasts. Eye Sci. 2014;29(4):214-218. [2]. Lee AL, et al. Injectable biodegradable hydrogels from vitamin D-functionalized polycarbonates for the delivery of avastin with enhanced therapeutic efficiency against metastatic colorectal cancer. Biomacromolecules. 2015;16(2):465-475.
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