Bevirimat(PA-457) Datasheet DC Chemicals
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Cat.No DC9643
Name Bevirimat(PA-457)

Chemical Properties

CAS 174022-42-5
Formula C36H56O6
MW 584.8263
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：174022-42-5
Product Name：Bevirimat
Synonyms：Bevirimat;(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-(3-carboxy-3-methylbutanoyl)oxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3;(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-(3-carboxy-3-methylbutanoyl)oxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid;BVM;DSB;FH11327;MPC-4326;PA-457;YK FH312;YK-FH312;(3b)-3-(3-Carboxy-3-methyl-1-oxobutoxy)lup-20(29)-en-28-oic acid;3-0-(3′-3′-Dimethylsuccinyl)betulinic acid;O-(3,3-Dimethylsuccinyl)betulinic acid;PA 457;Bevirimat(PA-457);3-O-(3',3'-Dimethylsuccinyl)betulinic acid;3-O-(3',3'-dimethylsuccinyl) betulinic acid;S125DW66N8;3-O-(3',3'-Dimethylsuccinyl)-betulinic acid;C36H56O6;Bevirimat [INN];bevirimatum;(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-(4-hydroxy-3,3-dimethyl-4-oxo-butanoy
EINEC:
Molecular Formula：C36H56O6
Molecular Weight：584.8263
Target:
In Vivo
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Smith PF, et al. Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection. Antimicrob Agents Chemother. 2007 Oct;51(10):3574-81. [2]. Salzwedel K, et al. Maturation inhibitors: a new therapeutic class targets the virus structure. AIDS Rev. 2007 Jul-Sep;9(3):162-72. [3]. Martin DE, et al. Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection. Antivir Chem Chemother. 2008;19(3):107-13.
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