(-)-Bicuculline methochloride Datasheet DC Chemicals
Description (-)-Bicuculline methochloride is an enantiomer of the GABA antagonist (+)-bicuculline methochloride. It increases the firing rate in rat cortical neurons similar to the (+) isomer but lacks GABA antagonist activity. (-)-Bicuculline methochloride inhibits sodium-independent GABA receptor binding with an IC50 value of 500 μM, which is approximately 100-fold less potent than (+)-bicuculline methochloride, but there is no stereoselectivity for sodium-dependent GABA receptor binding.
Cat.No DC36293
Name (-)-Bicuculline methochloride

Chemical Properties

CAS
Formula C21H20CLNO6
MW 417.84
Storage

References

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