Bragsin2 Datasheet DC Chemicals
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Cat.No DC12375
Name Bragsin2

Chemical Properties

CAS 342795-08-8
Formula C11H6F3NO5
MW 289.1643
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：342795-08-8
Product Name：Bragsin2
Synonyms：Bragsin2;STK838884;6-methoxy-5-nitro-2-trifluoromethylchromone;6-methoxy-5-nitro-2-(trifluoromethyl)-4H-chromen-4-one
EINEC:
Molecular Formula：C11H6F3NO5
Molecular Weight：289.1643
Target:
In Vivo
In Vitro Bragsin2 (50 μM) inhibits Arf GTPase activation in HeLa cells[1]. Bragsin2 (50 μM) inhibits the growth of SUM149 and S68, with no effect on SUM159, which lacks adhesion molecules such as integrins and cadherins[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Nawrotek A, et al. PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3.
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