Briciclib(ON 013105,ON 014185) Datasheet DC Chemicals
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Cat.No DC8179
Name Briciclib(ON 013105,ON 014185)

Chemical Properties

CAS 865783-99-9
Formula C19H23O10PS
MW 474.4187
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：865783-99-9
Product Name：Briciclib
Synonyms：Briciclib;2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methy l)phenyl dihydrogen phosphate;Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate);ON014185;ON-014185;WG93X96336;ON 014185;(E)-2-Methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl dihydrogen phosphate;Briciclib [USAN:INN];Phenol, 2-methoxy-5-((((1E)-2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl)-, 1-(dihydrogen phosphate);Briciclib (USAN/INN);Briciclib; ON 014185
EINEC:
Molecular Formula：C19H23O10PS
Molecular Weight：474.4187
Target:
In Vivo
In Vitro Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours[1].
Kinase Assay
Cell Assay
Animal Administration

References

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