Brincidofovir (CMX-001) Datasheet DC Chemicals
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Cat.No DC7761
Name Brincidofovir (CMX-001)

Chemical Properties

CAS 444805-28-1
Formula C27H52N3O7P
MW 561.69
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：444805-28-1
Product Name：CMX 001; HDP-cidofovir
Synonyms：[(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethyl-(3-hexadecoxypropoxy)phosphinic;[(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethyl-(3-hexadecoxypropoxy)phosphinic acid;BRINCIDOFOVIR;CMX 001;HDP-cidofovir;Hexadecyloxypropyl-cidofovir;[[(S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid mono[3-(hexadecyloxy)propyl] ester
EINEC:
Molecular Formula：C27H52N3O7P
Molecular Weight：561.69148
Target:
In Vivo
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Parker S, et al. Efficacy of therapeutic intervention with an oral ether-lipid analogue of cidofovir (CMX001) in a lethal mousepox model. Antiviral Res. 2008 Jan;77(1):39-49. [2]. Quenelle DC, et al. Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distributionstudies. J Infect Dis. 2010 Nov 15;202(10):1492-9. [3]. Gosert R, et al. CMX001 (1-O-hexadecyloxypropyl-cidofovir) inhibits polyomavirus JC replication in human brain progenitor-derived astrocytes. Antimicrob Agents Chemother. 2011 May;55(5):2129-36. [4]. Marty FM, et al. CMX001 to prevent cytomegalovirus disease in hematopoietic-cell transplantation. N Engl J Med. 2013 Sep 26;369(13):1227-36.
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