C12-200 is a well-known cationic lipid used in the formulation of lipid nanoparticles (LNPs) for the delivery of therapeutic nucleic acids, including siRNA, mRNA, and CRISPR components. It is widely recognized for its high in vivo potency at low doses and is often used as a positive control ionizable lipid in research exploring new ionizable lipids.
Cat.No
DC58046
Name
C12-200
Chemical Properties
CAS
1220890-25-4
Formula
C70N5O5H145
MW
1136.931
Storage
pure form: -20°C/3 years,4°C/2 years; In solvent: -20°C/1 month
References
1. Kevin T. Love, Kerry P. Mahon, Christopher G. Levins, Kathryn A. Whitehead, William Querbes,
J. Robert Dorkin, June Qin, William Cantley, Liu Liang Qin, Timothy Racie, Maria Frank-Kamenetsky,
Ka Ning Yip, Rene Alvarez, Dinah W. Y. Sah, Antonin de Fougerolles, Kevin Fitzgerald, Victor Koteliansky,
Akin Akinc, Robert Langer, Daniel G. Anderson, Proceedings of the National
Academy of Sciences, Feb 2010, 107 (5) 1864-1869; DOI: 10.1073/pnas.0910603106
2. Leuschner F, Courties G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva T, Borodovsky A,
Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin C,
Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M. Eur Heart J.
2015 Jun 14;36(23):1478-88. doi: 10.1093/eurheartj/ehu225. Epub 2014 Jun 20.
3. Kauffman KJ, Dorkin JR, Yang JH, Heartlein MW1, DeRosa F1, Mir FF, Fenton OS, Anderson DG. Nano Lett.
2015 Nov 11;15(11):7300-6. doi: 10.1021/acs.nanolett.5b02497. Epub 2015 Oct 20.
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