CO-1686 hydrobromide Datasheet DC Chemicals

Description	CO-1686 hydrobromide is a novel, irreversible and orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M (IC50=21 nM).
Cat.No	DC8651
Name	CO-1686 hydrobromide

Chemical Properties

CAS	1446700-26-0
Formula	C27H29BRF3N7O3
MW	636.4635
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Walter AO, et al. Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. Cancer Discov. 2013 Sep 25.

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