CRT0066854 Datasheet DC Chemicals
Description CRT-0066854 is a PKCι and PKCζ inhibitor. CRT0066854, was able to restore polarized morphogenesis in the dysplastic H-Ras spheroids. These results show that tightly regulated PKCι is required for normal-polarized morphogenesis in mammalian cells and that H-Ras and ErbB2 cooperate with PKCι for loss of polarization and dysplasia. The identification of a PKCι inhibitor that can restore polarized morphogenesis has implications for the treatment of Ras and ErbB2 driven malignancies.
Cat.No DC32557
Name CRT0066854

Chemical Properties

CAS 1438881-19-6
Formula C24H27CL2N5S
MW 488.475
Storage

References

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