CW069 Datasheet DC Chemicals
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Cat.No DC7392
Name CW069

Chemical Properties

CAS 1594094-64-0
Formula C23H21IN2O3
MW 500.3289
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：1594094-64-0
Product Name：(S)-2-(2-(Benzylamino)-3-phenylpropanamido)-5-iodobenzoic acid
Synonyms：CW 069;CW069;(S)-2-(2-(Benzylamino)-3-phenylpropanamido)-5-iodobenzoic acid;C23H21IN2O3;AOB2368;BCP27898;s7336;2342AH;SB19453;SW219359-1;A13735;2-[(2S)-2-(BENZYLAMINO)-3-PHENYLPROPANAMIDO]-5-IODOBENZOIC ACID;benzoic acid, 5-iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]-;CW-069
EINEC:
Molecular Formula：C23H21IN2O3
Molecular Weight：500.3289
Target:
In Vivo
In Vitro CW-069 is an allosteric inhibitor of HSET with an IC50 of 75 μM. CW-069 shows statistically significant selectivity over KSP. CW-069 potently suppresses N1E-115 cells, and less potently inhibits the NHDF cells, with IC50 of 86 ± 10 μM and 181 ± 7 μM, respectively. CW-069 (100 or 200 μM) causes increased multipolar spindles in N1E-115 cells with supernumerary centrosomes and shows no effect on altering bipolar spindle morphology in normal human dermal fibroblast cells. CW-069 (200 μM) cacuses multipolar anaphase and cell death induced in N1E-115 cells via transfection with HSET siRNA, and antagonizes inhibition of KSP by monastrol, but does not exert mitotic arrest in HeLa cells[1].
Kinase Assay
Cell Assay
Animal Administration

References

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