2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.:2408590-36-1 Product Name:CWI1-2 Synonyms:CWI1-2 EINECS: Molecular Formula:C22H17CL3N6O3 Molecular Weight:519.77
Target:
In Vivo
CWI1-2(5 mg/kg,i.v.,每日一次,7-10天)可显着延缓 BMT 受体 B6.SJL(CD45.1)小鼠白血病的发生和存活时间,体重无明显影响 [1]。
In Vitro
CWI1-2 (0-1 μM, 24 h) 具有良好的抗白血病功效[1]。 Apoptosis Analysis[1] Cell Line: MonoMac6, MOLM13 Concentration: 0-1 μM Incubation Time: 24 h Result: Induced significant cell differentiation and apoptosis in a concentration-dependent manner in IGF2BP2-high cells but not in IGF2BP2-low cells. Reduced Gln uptake and impaired mitochondrial function, resulting in reduced ATP production in AML cells. Significantly inhibited the colony-forming ability of MA9-induced leukemic mouse blasts and greatly impairs the self-renewal of LSC/LIC.
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Hengyou Weng, et al. The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10.
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