2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
Target:
In Vivo
In Vitro
Cyclovirobuxine D (0-240 µM ;24-72 hours) shows a concentration- and time-dependent reduced cell viability after CVB-D treatment, only 10% MGC-803 cells and 20% MKN28 cells are alive at 72 h after treatment with 240 µM[2]. Cyclovirobuxine D (0-120 µM; 48 hours) arrests the cell cycle of gastric cancer cells at S phase in a concentration-dependent manner[2]. Cyclovirobuxine D (0-120 µM; 48 hours) leads to apoptosis in gastric cancer cells in a concentration-dependent manner, especially early stage apoptosis.Cyclovirobuxine D (0-120 µM; 48 hours) causes apoptosis via up-regulation of the apoptosis- related proteins, cleaved Caspase-3 and ratio of Bax/Bcl-2, in gastric cancer cells[2]. Cell Viability Assay[2] Cell Line: MGC-803 and MKN28 cells Concentration: 0, 30, 60, 120 and 240 µM Incubation Time: 24, 48, 72 hours Result: Reduced Cell Viability and Colony Formation Ability of Gastric Cancer Cells Cell Cycle Analysis[2] Cell Line: MGC-803 and MKN28 cells Concentration: 0, 30, 60, and 120 µM Incubation Time: 48 hours Result: Arrested cell cycle progressions of MGC-803 and MKN28 cells. Apoptosis Analysis[2] Cell Line: MGC-803 and MKN28 cells Concentration: 0, 30, 60, and 120 µM Incubation Time: 48 hours Result: Induced apoptosis of MGC-803 and MKN28 cells. Western Blot Analysis[2] Cell Line: MGC-803 and MKN28 cells Concentration: 0, 30, 60, and 120 µM Incubation Time: 48 hours Result: Up-regulated cleaved Caspase-3 and Bax and decreased the expression of Bcl-2 expression.
Kinase Assay
Cell Assay
Animal Administration
References
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