NTN21277(Gefitinib-based PROTAC 3) Datasheet DC Chemicals

Description	Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.
Cat.No	DC11002
Name	NTN21277(Gefitinib-based PROTAC 3)

Chemical Properties

CAS	2230821-27-7
Formula	C47H57CLFN7O8S
MW	934.522
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3.

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