2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：1358575-02-6
Product Name：4-(3-(3-Fluoro-5-(trifluoromethyl)benzyl)-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide
Synonyms：
EINEC:
Molecular Formula：C19H16F4N4O
Molecular Weight：392.35
Target:
IC50: 75 nM (GPR52)[1].
In Vivo
FTBMT (30 mg/kg) exhibits antipsychotic-like activity without causing catalepsy in mice[2].
In Vitro
FTBMT (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50s of 7.03 6 0.04, 6.85 6 0.02, and 6.87 6 0.02[2].
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Tokumaru K, et al. Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg Med Chem. 2017 Jun 15;25(12):3098-3115.
[2]. Nishiyama K, et al. FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia. J Pharmacol Exp Ther. 2017 Nov;363(2):253-264.
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