Chemical Properties
| CAS |
312608-54-1 |
 |
| Formula |
C12H11N3O4S |
| MW |
293.3 |
| Storage |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Biological activity
| Description |
CAS NO.：312608-54-1
Product Name：4-Ethoxy-N-(5-nitrothiazol-2-yl)benzamide
Synonyms：ChemBridge5655896;MID 1;MID1
EINECS:
Molecular Formula：C12H11N3O4S
Molecular Weight：293.30 |
| Target: |
|
| In Vivo |
MID-1 does not have good pharmacokinetics in vivo[1]. |
| In Vitro |
MID-1 (5 μM; 24 h) increases the IRS-1 expression level in skeletal muscle by disrupting the MG53-IRS-1 interaction[1]. MID-1 (10 μM; 12 h) reduces the luciferase activity in HEK 293 cell line expressing NLUC-IRS-1 and CLUC-C14A[1]. MID-1 (1-20 μM; 12 h) disrupts the MG53-IRS-1 interaction but not MG53-FAK interaction in HEK 293 cells[1]. MID-1 (0.1-10 μM; 4-24 h) abolishes MG53-induced IRS-1 ubiquitination and degradation in HEK 293 cells[1]. MID-1 (5-10 μM; 24 h) increases insulin signaling and insulin-elicited glucose uptake in C2C12 myotubes[1]. MID-1 (5-10 μM; 24 h) enhances skeletal myogenesis[1]. Western Blot Analysis[1] Cell Line: C2C12 myotubes Concentration: 5 μM Incubation Time: 24 h Result: Increased the IRS-1 protein level. |
| Kinase Assay |
|
| Cell Assay |
|
| Animal Administration |
|
References
|
Return Policy
If you are in any way unsatisfied with your purchase, you may return any item(s) within 365 days of its original purchase date.
Please provide your Order Number in the email. We strive to reply to all email inquiries within one business day.
Tel: +86-21-58447131
Fax: +86-21-61642470
Email:
sales@dcchemicals.com
order@dcchemicals.com
Website:
www.dcchemicals.com
|
