AF64394 Datasheet DC Chemicals
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Cat.No DC11170
Name AF64394

Chemical Properties

CAS 1637300-25-4
Formula C21H20CLN5O
MW 393.8694
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：1637300-25-4
Product Name：N-[(4-Chloro-2-propan-2-yloxyphenyl)methyl]-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Synonyms：AF64394;(4-Chloro-2-isopropoxy-benzyl)-(5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-amine;N-(4-chloro-2-isopropoxybenzyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine;BCP29864;AF 64394;AK00799739;N-[[4-Chloro-2-(1-methylethoxy)phenyl]methyl]-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine;N-[(4-Chloro-2-propan-2-yloxyphenyl)methyl]-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
EINEC:
Molecular Formula：C21H20CLN5O
Molecular Weight：393.8694
Target: pIC50: 7.3 (GPR3)[1].
In Vivo
In Vitro AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3. AF34394 and related compounds are only of modest potency and are relatively lipophilic (e.g., AF34394 clogP=5.2, LLE=2.1, and 14b clog P=3.1 and LLE=3.2) the series shows promising SAR and represents an excellent start point for further optimization[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Jensen T, et al. The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5195-8.
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