AMG-333 Datasheet DC Chemicals

Description	AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM.
Cat.No	DC11239
Name	AMG-333

Chemical Properties

CAS	1416799-28-4
Formula	C20H12F5N3O4
MW	453.319002151489
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Horne DB, et al. Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine. J Med Chem. 2018 Sep 27;61(18):8186-8201.

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