Chemical Properties
| CAS |
1338259-05-4 |
 |
| Formula |
C33H29N3O5 |
| MW |
547.6 |
| Storage |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Biological activity
| Description |
CAS NO.：1338259-05-4
Product Name：4'-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-[1,1'-biphenyl]-2-carboxylic acid
Synonyms：SR 1664;SR1664
EINEC:
Molecular Formula：C33H29N3O5
Molecular Weight：547.6 |
| Target: |
PPAR-γ:80 nM (IC50) |
| In Vivo |
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| In Vitro |
SR1664 (1uM; HEK293T cells) pharmacological effect on PPARγ activity is altered by mutagenesis of F282 to alanine (F282A)[1]. |
| Kinase Assay |
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| Cell Assay |
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| Animal Administration |
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References
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[1]. Marciano DP, Kuruvilla DS, Boregowda SV, et al. Pharmacological repression of PPARγ promotes osteogenesis. Nat Commun. 2015;6:7443. Published 2015 Jun 12.
[2]. Choi JH, et al. Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature. 2011;477(7365):477-481. Published 2011 Sep 4. |
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