BAY-678 Datasheet DC Chemicals

Description	BAY-678 is a cell-permeable inhibitor of human neutrophil elastase (HNE).
Cat.No	DC11858
Name	BAY-678

Chemical Properties

CAS	675103-36-3
Formula	C20H15F3N4O2
MW	400.360
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73. [2]. von Nussbaum F, et al. Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4370-81.

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