2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：1426698-88-5 Product Name：Parsaclisib Synonyms：Parsaclisib;INCB050465;Parsaclisib free base;OS7097575K;(4R)-4-{3-[(1S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl}pyrrolidin-2-one;(4R)-4-(3-((1S)-1-(4-Amino-3-methyl-1H-pyrazolo(3,4-d)pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one;Parsaclisib [INN];Parsaclisib [USAN];Parsaclisib (USAN/INN);Parsaclisib [USAN:INN];INCB050465 free base EINEC: Molecular Formula：C20H22CLFN6O2 Molecular Weight：432.879086017609
Target:
In Vivo
In Vitro
Parsaclisib (INCB050465) is a potent and selective PI3Kδ with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. Parsaclisib displays significant activity with IC50 values ranging from 0.2 to 2 nM in B and T cell proliferation aaasys. Parsaclisib inhibits proliferation of several DLBCL and MCL cell lines in vitro (EC50 < 10 nM)[1].
Kinase Assay
Cell Assay
Animal Administration
References
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