PD 184161 Datasheet DC Chemicals

Description	A potent, orally-active MEK1/2 inhibitor with IC50 of 10-100 nM.
Cat.No	DC11959
Name	PD 184161

Chemical Properties

CAS	212631-67-9
Formula	C17H13BRCLF2IN2O2
MW	557.56
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Klein PJ, et al. The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer. Neoplasia. 2006 Jan;8(1):1-8. [2]. Duman CH, et al. A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment. Biol Psychiatry. 2007 Mar 1;61(5):661-70. [3]. Gladbach A, et al. ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke. J Neural Transm (Vienna). 2014 May;121(5):543-7.

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