2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：1863905-38-7 Product Name：Chembl4203759 Synonyms：2-((3R,4S)-3-Fluoro-1-(2-(4-(trifluoromethoxy)phenyl)acetyl)piperidin-4-yloxy)-4-(2-hydroxy-2-methylpropoxy)benzamide;2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-4-(2-hydroxy-2-methylpropoxy)benzamide;TQR0432;BDBM50457827;2-(((3R,4S)-3-fluoro-1-(2-(4-(trifluoromethoxy)phenyl)acetyl)piperidin-4-yl)oxy)-4-(2-hydroxy-2-methylpropoxy)benzamide;GO7;Chembl4203759 EINEC: Molecular Formula：C25H28F4N2O6 Molecular Weight：528.4932
Target:
TrkA:7.7 nM (IC50, in cell-based assays)
TrkB:15 nM (IC50, in cell-based assays)
TrkC:3.9 nM (IC50, in cell-based assays)
In Vivo
In Vitro
PF-06737007 (Compound 13b) exhibits superb Trk selectivity with >95% inhibition of TrkA with no other kinase being inhibited by >40% at 1 μM[1].
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800.
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