GPR4 antagonist 3(NE 52-QQ57 ) Datasheet DC Chemicals
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Cat.No DC20076
Name GPR4 antagonist 3(NE 52-QQ57 )

Chemical Properties

CAS 1401728-56-0
Formula C24H28N6O
MW 416.52
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：1401728-56-0
Product Name：
Synonyms：NE 52-QQ57
EINECS:
Molecular Formula：C24H28N6O
Molecular Weight：416.52
Target: IC50: 70 nM (GPR4)[1].
In Vivo GPR4 antagonist 3 shows a significant anti-inflammatory effect in the rat antigen induced arthritis model after oral administration at 30 mg/kg bid[1].GPR4 antagonist 3 also prevents angiogenesis in the mouse chamber model as well as pain as demonstrated in the rat complete Freund’s adjuvant model[1].
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Velcicky J, et al. Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis. J Med Chem. 2017 May 11;60(9):3672-3683.
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