GT 949 Datasheet DC Chemicals
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Cat.No DC20112
Name GT 949

Chemical Properties

CAS 460330-27-2
Formula C30N7O2H37
MW 527.6605
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：460330-27-2
Product Name：3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one
Synonyms：GT 949
EINEC:
Molecular Formula：C30N7O2H37
Molecular Weight：527.6605
Target: EC50: 0.26±0.03 nM (EAAT2)[1]
In Vivo
In Vitro GT 949 (GT949) enhances glutamate transport with an EC50 of 0.26 ± 0.03 nM. GT 949 also demonstrates selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3[1]. GT 949 is also tested for its effect on glutamate uptake kinetics in EAAT2-transfected cells. GT 949 enhances glutamate transport in a noncompetitive fashion, with increase in Vmax of about 47%[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Kortagere S, et al. Identification of Novel Allosteric Modulators of Glutamate Transporter EAAT2. ACS Chem Neurosci. 2018 Mar 21;9(3):522-534.
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