NRX-252114 Datasheet DC Chemicals
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Cat.No DC20252
Name NRX-252114

Chemical Properties

CAS 2763260-39-3
Formula C22H12CL2F3N3O2S
MW 510.31579208374
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：2763260-39-3
Product Name：NRX-252114
Synonyms：1H-Isoindole-4-carbonitrile, 2-[[4-[(2,6-dichlorophenyl)thio]-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-pyridinyl]carbonyl]-2,3-dihydro-;NRX-252114
EINEC:
Molecular Formula：C22H12CL2F3N3O2S
Molecular Weight：510.31579208374
Target: EC50: 6.5 nM (β-catenin:β-TrCP Interaction) Kd: 0.4 nM (β-catenin:β-TrCP Interaction)
In Vivo
In Vitro NRX-252114 (20 μM) enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP, with more than 1500-fold co-operativity. NRX-252114 (0-25 μM) increases the ubiquitylation of pSer33/S37A β-catenin peptide to form long ubiquitin chains. NRX-252114 (0-25 μM) enhances the ubiquitylation of S33E/S37A β-catenin protein, as well as unphosphorylated Ser33/S37A β-catenin peptides. NRX-252114 (20 μM, 6 h) results in robust S33E/S37A β-catenin:β-TrCP interaction in the transfected HEK293T cells.
Kinase Assay
Cell Assay
Animal Administration

References

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