MJ-III-65 (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[2]. Animal Model: Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[2]. Dosage: 10, 25, or 50 mg/kg/week, 4 weeks Administration: i.v. push via tail vein Result: moderately actived against human A253 and FaDu tumor xenografts without significant toxicity
In Vitro
The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM[1]. LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[1]. Cell Cytotoxicity Assay[1] Cell Line: P388 and P388 Top1-deficient murine leukemia cells Concentration: 0.1-100 μM Incubation Time: 3 days Result: induced dose-dependent accumulation of cells in the S and G2 phases of the cell cycle
Kinase Assay
Cell Assay
Animal Administration
References
Return Policy
If you are in any way unsatisfied with your purchase, you may return any item(s) within 365 days of its original purchase date.
Please provide your Order Number in the email. We strive to reply to all email inquiries within one business day.
