2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：21373-30-8 Product Name：Tyrosine,2,5-dihydroxy- Synonyms：Tyrosine,2,5-dihydroxy- EINEC: Molecular Formula：C9H11NO5 Molecular Weight：213.187342882156
Target:
RAD52[1]
In Vivo
In Vitro
6-Hydroxy-DOPA (0~20 μM; U20S cells) selectively inhibits RAD52-mediated recombination. 6-Hydroxy-DOPA (0~10 μM; HEK293T cells) decreases the number of eGFP-RAD52 foci in a dose-dependent manner. 6-Hydroxy-DOPA (5~75 μM; HCC1937 cells) selectively reduces the viability of the BRCA1-deficient triple-negative breast cancer cell line HCC1937[1].
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Chandramouly G, et al. Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem Biol. 2015;22(11):1491-1504.
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